
Reductil(Europe, also known as Meridia in USA) is another common anti-obesity medicine. It was approved by FDA in 1997. The active ingredient is sibutramine, and it comes in a 10mg capsule. Dosage is 10 mg once daily (usually in the morning). If this is insufficient the dose may be increased to 15 mg daily after 4 weeks.
So how does Reductil work?
It's main mechanism of action is by affecting neurotransmitters in the brain. Sibutramine prevents two of these neurotransmitters, noradrenaline and serotonin, from being reabsorbed back into the nerve cells. Noradrenaline and serotonin are responsible for moderating mood and various other processes in the brain.
It is thought that sibutramine helps people to lose weight by increasing the amount of noradrenaline and serotonin free to act in the brain. This enhances the feeling of fulfillment from eating, and so makes you feel satisfied after eating less food.
An appropriate diet and exercise programme should be started while taking this medicine, in order to maintain your new weight after you have stopped treatment. Please consult your doctor for a full customised weight loss programme.
Who cannot take Reductil?
You cannot take Reductil if you are/have:
- psychiatric conditions such as bulimia, anorexia, depression or preexisting mania
- a history of or a predisposition to drug or alcohol abuse
- taking a MAO inhibitor, antidepressant or other centrally acting drugs
- poorly controlled hypertension
- heart disease
- stroke or seizu
- hyperthyroidism
- closed angle glaucoma
- enlarged prostate with urinary retention
- Phaeochromocytoma
- pregnant, or breast-feeding a child
General Precautions with Reductil:
- Reductil capsules should be swallowed whole with or without food.
- This medicine may reduce your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
- You should change your lifestyle in terms of eating habits and physical activity while taking this medicine, so that you are able to maintain your new weight after you have stopped treatment. Your doctor should advise you on the changes you need to make and continue to monitor your weight after you stop treatment. If you don't change your lifestyle you may regain the weight you have lost.
- Your weight should be monitored while you are taking this medicine. If you are not responding adequately to this medicine, ie if you have not lost at least five per cent of your body weight within three months, or if you put on more than 3kg at any stage after previously losing weight, you will need to stop taking this medicine. This medicine should not be taken for longer than one year.
- Your blood pressure and pulse rate should be monitored while you are taking this medication; every two weeks for the first three months, then once a month for the next three months, then regularly at maximum intervals of three months after that. Your doctor may ask you to stop taking this medicine if your blood pressure or pulse rate increase too much.
- Consult your doctor if you experience shortness of breath, chest pain or ankle swelling while taking this medicine.
- If you experience any mood changes, depression, or distressing thoughts or feelings while taking this medicine then it is very important to talk to your doctor.
- This medicine may be harmful to an unborn baby. Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while using this medicine.
Some possible common side effects of Xenical
- Dry mouth
- Difficulty in sleeping (insomnia)
- Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
- Headache
- Pins and needles (paraesthesia)
- Lightheadedness
- Anxiety
- Sweating
- Alteration in taste
- Aggravation of haemorrhoids
- Hot flushes
- Awareness of your heartbeat (palpitations)
- Increased heart rate (tachycardia)
- Raised blood pressure (hypertension)
- Depression
- Menstrual cycle disorders
- Impotence
- Seizures
- Decrease in the number of platelets in the blood (thrombocytopenia)
- Kidney disorders
*Please consult your doctor for a full assessment before starting Reductil.
*Prescription-only medicine. Please buy from a reliable source.